For the past 20 years, Canadians have been at the forefront of research into cystic fibrosis, by mapping and isolating the gene involved. While this disease is caused by a single gene, its severity cannot be explained simply by the mutation of that particular gene. Additional genetic factors (called modifier genes) and environmental factors are also thought to influence the symptoms and course of this disease.
In this project, the researchers are identifying the modifier genes through a systematic analysis of the Canadian population with cystic fibrosis. This involves collecting patient samples from across the country, updating and improving the cystic fibrosis patient registry, and mapping and analyzing genes thought to be linked to this disease.
A better understanding of the modifier genes will lead to new therapies for cystic fibrosis. The research findings may also help to explain molecular mechanisms in other diseases.
Led by scientists at the Hospital for Sick Children in Toronto, this project also involves researchers from the University of British Columbia and the University of Montreal.