User: National Research Council Canada
This project aims to develop a new tool to better analyze the genetic material inside virus-based therapies, which are used in gene therapy to deliver DNA or RNA into cells. However, the genetic material inside these viruses is not always complete, which can reduce treatment effectiveness or safety.
Using advanced long-read DNA/RNA sequencing, the project will improve methods for preparing and analyzing viral samples and study how design and production choices impact their quality. By combining lab experiments, sequencing, and computer analysis, this work will make viral therapies safer, more reliable, and more effective, while supporting the development of next-generation therapies and reducing manufacturing costs.