{"id":16527,"date":"2012-12-17T00:00:00","date_gmt":"2012-12-17T05:00:00","guid":{"rendered":"https:\/\/genomequebec.com\/actualites-et-publications\/a-genetic-defect-in-sex-cells-may-predispose-to-childhood-leukemia\/"},"modified":"2012-12-17T00:00:00","modified_gmt":"2012-12-17T05:00:00","slug":"a-genetic-defect-in-sex-cells-may-predispose-to-childhood-leukemia","status":"publish","type":"post","link":"https:\/\/genomequebec.com\/en\/news-and-publications\/a-genetic-defect-in-sex-cells-may-predispose-to-childhood-leukemia\/","title":{"rendered":"A genetic defect in sex cells may predispose to childhood leukemia"},"content":{"rendered":"<p style=\"text-align: left;\" align=\"center\"><em>Rare atypical form of the PRDM9 fertility gene found in parents<\/em><\/p>\n<p>Researchers at the Sainte-Justine University Hospital Center and the University of Montreal have found a possible heredity mechanism that predisposes children to acute lymphoblastic leukemia (ALL), the most common type of blood cancer in children. According to their findings published in <em>Genome Research, <\/em>the presence of a genetic defect in the egg or sperm that give rise to children with ALL may be a prerequisite for the disease to develop.<\/p>\n<p>A significant number of children with ALL are thought to inherit a rare PRDM9 gene variant responsible for the abnormal sex cells\u2013a gene variant that puts their own children at risk of having ALL-predisposed offspring.<\/p>\n<p>\u00a0<\/p>\n<p>\u201cOur findings indicate ALL susceptibility to be partially hereditary. However, it is not classic heredity in the sense that the abnormal genetic variant does not need to be passed from parent to child for offspring to have the disease,\u201d explains Julie Hussin, a doctoral student in Genomics under the direction of Dr. Philip Awadalla, a genetics researcher.<\/p>\n<p>\u00a0<\/p>\n<p>\u201cInstead, the genetic defect in the egg or sperm from which the children developed is thought to predispose them to leukemia,\u201d continues Julie Hussin. \u201cHowever, only the children who inherit the genetic variant run the risk of transmitting ALL predispositions to their offspring.\u201d According to the study, more than three quarters of families with affected children have an atypical form of the PRDM9 gene, with half the patients inheriting this genetic variant. The defect is expressed at unusual positions along chromosomes during formation of eggs in females, or sperm in males.<\/p>\n<p>To read de press release: <a href=\"http:\/\/www.nouvelles.umontreal.ca\/udem-news\/index.php\" target=\"_blank\" rel=\"noopener\">http:\/\/www.nouvelles.umontreal.ca\/udem-news\/index.php<\/a><\/p>\n<p>To learn more: <em>Genome Research<\/em> le 5 d\u00e9cembre 2012<\/p>\n<p><a href=\"http:\/\/genome.cshlp.org\/content\/early\/2012\/12\/05\/gr.144188.112.abstract\" target=\"_blank\" rel=\"noopener\">http:\/\/genome.cshlp.org\/content\/early\/2012\/12\/05\/gr.144188.112.abstract<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Rare atypical form of the PRDM9 fertility gene found in parents Researchers at the Sainte-Justine University Hospital Center and the University of Montreal have found a possible heredity mechanism that&hellip;<\/p>\n","protected":false},"author":1,"featured_media":15294,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[294],"tags":[],"class_list":["post-16527","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nouvelles"],"acf":[],"_links":{"self":[{"href":"https:\/\/genomequebec.com\/en\/wp-json\/wp\/v2\/posts\/16527","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/genomequebec.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/genomequebec.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/genomequebec.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/genomequebec.com\/en\/wp-json\/wp\/v2\/comments?post=16527"}],"version-history":[{"count":0,"href":"https:\/\/genomequebec.com\/en\/wp-json\/wp\/v2\/posts\/16527\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/genomequebec.com\/en\/wp-json\/wp\/v2\/media\/15294"}],"wp:attachment":[{"href":"https:\/\/genomequebec.com\/en\/wp-json\/wp\/v2\/media?parent=16527"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/genomequebec.com\/en\/wp-json\/wp\/v2\/categories?post=16527"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/genomequebec.com\/en\/wp-json\/wp\/v2\/tags?post=16527"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}