{"id":31326,"date":"2025-06-02T13:13:36","date_gmt":"2025-06-02T17:13:36","guid":{"rendered":"https:\/\/genomequebec.com\/?post_type=financed-project&#038;p=31326"},"modified":"2025-06-02T13:13:42","modified_gmt":"2025-06-02T17:13:42","slug":"nature-versus-nurture-of-glucose-homeostasis-trajectories-in-children-across-different-ancestries","status":"publish","type":"financed-project","link":"https:\/\/genomequebec.com\/en\/funded-projects\/nature-versus-nurture-of-glucose-homeostasis-trajectories-in-children-across-different-ancestries\/","title":{"rendered":"Nature versus nurture of glucose homeostasis trajectories in children across different ancestries"},"content":{"rendered":"\n<p>Type 2 diabetes was previously rare in children, but its prevalence in this age group is increasing as a result of the pediatric obesity epidemic, especially in non-European youth. First Nations children present the highest rates of this disease. The prevalence of prediabetes is also increasing in adolescents.<\/p>\n\n\n\n<p>Dr Manousaki\u2019s research focuses on abnormal glucose metabolism, or \u201cdysglycemia\u201d, which encompasses type 2 diabetes and prediabetes. In order to better understand the progression of type 2 diabetes in children, the research project aims to:<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Develop a tool for early prediction of dysglycemia using a combination of genetic and other known risk factors<\/li>\n\n\n\n<li>Determine whether a favorable environment and healthy lifestyle habits at an early age can counteract a genetic predisposition to dysglycemia<\/li>\n\n\n\n<li>Characterize the age-, gender- and ethno-cultural-specific pathophysiological mechanisms that encompass glucose metabolic trajectories in childhood.<\/li>\n<\/ol>\n\n\n\n<p>This project will draw on diverse ancestries and rely on two North American cohorts of children at risk of obesity, a Canadian cohort of First Nations children, and a UK cohort of children and their parents.<\/p>\n\n\n\n<p>As type 2 diabetes becomes increasingly prevalent among youth, this project represents a step towards identifying those most at risk, with the ultimate goal of informing public health measures to better support children in Canada.<\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-31326","financed-project","type-financed-project","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/genomequebec.com\/en\/wp-json\/wp\/v2\/financed-project\/31326","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/genomequebec.com\/en\/wp-json\/wp\/v2\/financed-project"}],"about":[{"href":"https:\/\/genomequebec.com\/en\/wp-json\/wp\/v2\/types\/financed-project"}],"wp:attachment":[{"href":"https:\/\/genomequebec.com\/en\/wp-json\/wp\/v2\/media?parent=31326"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}