Breast cancer is the most common cancer in women in Canada and the second-leading cause of cancer death. Women face a one-in-eight chance of developing cancer in their lifetime. Current recommendations are that all women aged 50-74 have a screening mammogram every two-to-three years. Screening instead according to risk, through a combination of genomic profiling and other breast cancer risk factors, would enhance the benefits and reduce the risks of screening.<\/p>\n
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The evidence generated by this research project will support the transition from population-based to risk-based screening. It will also improve counseling for women with a family history of breast cancer who are seen in cancer genetic clinics. This improved approach to screening will enable earlier detection and treatment of breast cancer, saving lives and bringing health and socio-economic benefits.<\/p>\n
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The research team, led by Drs. Jacques Simard of Universit\u00e9 Laval and Anna Maria Chiarelli of the University of Toronto, will study large cohorts of women using high throughput genomic technologies, together with statistical and epidemiological methods, to develop and validate a multi-gene panel test based on genetic variations associated with breast cancer. The team will also assess the acceptability and feasibility of using a new, comprehensive risk-prediction web-based tool and a genomic profiling test within the existing mammography screening system.<\/p>\n
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The results of this project will change breast-screening practice and ensure better use of human and financial resources, while reducing the burden of breast cancer on Canadian women.<\/p>\n
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Short version<\/strong><\/p>\n This project will support a transformation in breast-cancer screening from a population-based approach to one based on risk. The research team will develop a multi-gene test based on genetic variations associated with breast cancer, to be used within existing mammography programs to ensure earlier detection and treatment of breast cancer and more efficient use of human and financial resources.<\/p>\n \u00a0<\/p>\n Lead Genome Centre:\u00a0<\/strong>G\u00e9nome Qu\u00e9bec<\/p>\n Co-lead Genome Centre:\u00a0<\/strong>Ontario Genomics<\/p>\n \u00a0<\/p>\n Co-project leader and User:<\/strong><\/p>\n \u00a0<\/p>\n Co-applicants, Users and Collaborators:<\/strong><\/p>\n Centre de recherche du CHU de Qu\u00e9bec – Universit\u00e9 Laval<\/span><\/p>\n<\/td>\n<\/tr>\n\n
\n Anna Maria<\/td>\n Chiarelli<\/td>\n Cancer Care Ontario, University of Toronto<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n \n
\n Irene<\/td>\n Andrulis<\/td>\n University of Toronto<\/td>\n<\/tr>\n \n Antonis<\/td>\n Antoniou<\/td>\n University of Cambridge, Cambridge, United Kingdom<\/td>\n<\/tr>\n \n Jennifer<\/td>\n Brooks<\/td>\n University of Toronto<\/td>\n<\/tr>\n \n Jocelylne<\/td>\n Chiquette<\/td>\n Universit\u00e9 Laval<\/td>\n<\/tr>\n \n Peter<\/td>\n Devilee<\/td>\n Leiden University Medical Center, Leiden, The Netherlands<\/td>\n<\/tr>\n \n Michel<\/td>\n Dorval<\/td>\n Universit\u00e9 Laval<\/td>\n<\/tr>\n \n Arnaud<\/td>\n Droit<\/td>\n Universit\u00e9 Laval<\/td>\n<\/tr>\n \n Douglas<\/td>\n Easton<\/td>\n University of Cambridge, Cambridge, United Kingdom<\/span><\/td>\n<\/tr>\n \n Andrea<\/td>\n Eisen<\/td>\n Sunnybrook Health Science Centre<\/td>\n<\/tr>\n \n Laurence<\/td>\n Eloy<\/td>\n Minist\u00e8re de la Sant\u00e9 et des Services sociaux du Qu\u00e9bec<\/td>\n<\/tr>\n \n David<\/td>\n Goldgar<\/td>\n University of Utah,\u00a0Salt Lake City, United States<\/span><\/td>\n<\/tr>\n \n Yann<\/td>\n Joly<\/td>\n McGill University<\/td>\n<\/tr>\n \n Suzanne<\/td>\n Kamel-Reid<\/td>\n University of Toronto<\/td>\n<\/tr>\n \n Bartha Maria<\/td>\n Knoppers<\/td>\n McGill University<\/td>\n<\/tr>\n \n Jean-Yves<\/td>\n Masson<\/td>\n \n \n Nicole<\/td>\n Mittmann<\/td>\n University of Toronto<\/td>\n<\/tr>\n \n Hermann<\/td>\n Nabi<\/td>\n Universit\u00e9 Laval<\/td>\n<\/tr>\n \n Nora<\/td>\n Pashayan<\/td>\n University College London, London, United Kingdom<\/td>\n<\/tr>\n \n Rita<\/td>\n Schmutzler<\/td>\n University Hospital Cologne,\u00a0K\u00f6ln, Germany<\/span><\/span><\/td>\n<\/tr>\n \n Tracy<\/td>\n Stockley<\/td>\n University of Toronto<\/td>\n<\/tr>\n \n Sean<\/td>\n Tavtigian<\/td>\n University of Utah,\u00a0<\/span>Salt Lake City, United States<\/td>\n<\/tr>\n \n Haico<\/td>\n van Attikum<\/td>\n Leiden University Medical Center, Leiden, The Netherlands<\/span><\/td>\n<\/tr>\n \n Meghan<\/td>\n Walker<\/td>\n Cancer Care Ontario<\/td>\n<\/tr>\n \n Michael<\/td>\n Wolfson<\/td>\n University of Toronto<\/td>\n<\/tr>\n \n Linda<\/td>\n Rabeneck<\/td>\n Cancer Care Ontario<\/td>\n<\/tr>\n \n Nathalie<\/td>\n Tremblay<\/td>\n Quebec Breast Cancer Foundation<\/td>\n<\/tr>\n \n Jean<\/td>\n Latreille<\/td>\n Minist\u00e8re de la Sant\u00e9 et des Services sociaux du Qu\u00e9bec<\/td>\n<\/tr>\n \n Karen<\/td>\n Malone<\/td>\n Canadian Cancer Society<\/td>\n<\/tr>\n \n Nicole\u00a0<\/td>\n Beben<\/td>\n Canadian Partnership Against Cancer<\/td>\n<\/tr>\n \n Rami<\/td>\n Rahal<\/td>\n Canadian Partnership Against Cancer<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"featured_media":0,"template":"","class_list":["post-25838","financed-project","type-financed-project","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/genomequebec.com\/en\/wp-json\/wp\/v2\/financed-project\/25838","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/genomequebec.com\/en\/wp-json\/wp\/v2\/financed-project"}],"about":[{"href":"https:\/\/genomequebec.com\/en\/wp-json\/wp\/v2\/types\/financed-project"}],"wp:attachment":[{"href":"https:\/\/genomequebec.com\/en\/wp-json\/wp\/v2\/media?parent=25838"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}