{"id":25773,"date":"2023-05-24T10:17:40","date_gmt":"2023-05-24T14:17:40","guid":{"rendered":"https:\/\/genomequebec.com\/financed-project\/recherche-quebecoise-sur-la-pharmacogenomique-cardiovasculaire\/"},"modified":"2023-05-24T10:27:10","modified_gmt":"2023-05-24T14:27:10","slug":"recherche-quebecoise-sur-la-pharmacogenomique-cardiovasculaire","status":"publish","type":"financed-project","link":"https:\/\/genomequebec.com\/en\/funded-projects\/recherche-quebecoise-sur-la-pharmacogenomique-cardiovasculaire\/","title":{"rendered":"Recherche qu\u00e9b\u00e9coise sur la pharmacog\u00e9nomique cardiovasculaire"},"content":{"rendered":"<p style=\"text-align: justify;\">Building towards the clinical application of pharmacogenomics in the treatment of cardiovascular diseases.\u00a0This project, led by D<sup>rs<\/sup> Jean-Claude Tardif and Michael Phillips from the Montreal Heart Institute, in partnership with VIA Pharmaceuticals, aims at continuing the development of the necessary framework to support pharmacogenomics clinical trials in cardiovascular diseases in Qu\u00e9bec andCanada. Acute Coronary Syndrome (ACS) is a leading cause of morbidity and mortality in western countries. To address this issue, VIA Pharmaceuticals is developing the drug VIA-2291, a potent inhibitor of an enzymatic protein (5-lipoxygenase) believed to play a key role in the pathogenesis of several human diseases, including atherosclerosis, the main contributor to ACS. Through this PRIVAC research project, the G\u00e9nome Qu\u00e9bec \/ Montreal Heart Institute Pharmacogenomics Centre will be working with VIA Pharmaceuticals to conduct a clinical pharmacogenomics research study in order to better understand the genetic variation that may affect individual\u2019s response to VIA-2291.\u00a0This project will be made possible thanks to the establishment of strategic partnerships with the private sector for critical technological developments: Agencourt BioScience will contribute to the development of rapid clinical methods to support DNA isolation, and Invitrogen will support the technological improvements genotyping and medical re-sequencing. In addition, collaboration with Illumina will insure for the G\u00e9nome Qu\u00e9bec \/ Montreal Heart Institute Pharmacogenomics Centre excellent opportunities of knowledge transfer and commercialisation of standardized pharmacogenomic tests developed through this project and which will have broad applicability across the pharmaceutical industry. Development of cutting edge bioinformatics infrastructure within the Pharmacogenomic Centerwill further contribute to this knowledge transfer.\u00a0This project will be at the forefront of innovation in Pharmacogenomics and further strengthen the leadership of Qu\u00e9bec in this research area. In addition, the tangible outcomes to be expected through the Pharmacogenomics platform services and the integration of pharmacogenomic arms to clinical studies brings closer personalized medicine to all of us.<\/p>\n<p style=\"text-align: justify;\">\u00a0<\/p>\n<p style=\"text-align: justify;\"><strong>Co-applicants:<\/strong><\/p>\n<table style=\"width: 735px;\" border=\"0\" cellspacing=\"0\" cellpadding=\"0\">\n<colgroup>\n<col span=\"2\" width=\"112\" \/>\n<col width=\"511\" \/><\/colgroup>\n<tbody>\n<tr>\n<td class=\"xl65\" width=\"112\" height=\"19\">Nathalie<\/td>\n<td class=\"xl65\" width=\"112\">Laplante<\/td>\n<td class=\"xl66\" width=\"511\">Montreal Heart Institute<\/td>\n<\/tr>\n<tr>\n<td class=\"xl65\" height=\"19\">Tibor<\/td>\n<td class=\"xl65\">van Rooij<\/td>\n<td class=\"xl66\">Montreal Heart Institute<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p style=\"text-align: justify;\">\u00a0<\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-25773","financed-project","type-financed-project","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/genomequebec.com\/en\/wp-json\/wp\/v2\/financed-project\/25773","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/genomequebec.com\/en\/wp-json\/wp\/v2\/financed-project"}],"about":[{"href":"https:\/\/genomequebec.com\/en\/wp-json\/wp\/v2\/types\/financed-project"}],"wp:attachment":[{"href":"https:\/\/genomequebec.com\/en\/wp-json\/wp\/v2\/media?parent=25773"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}