Tuberculosis has been resurgent recently, with ~9 million cases and 1.7 million deaths in 2004, and represents the leading cause of death from a curable disease. This upsurge is due in part to: the HIV epidemic, population migration and the emergent evolution of antibiotics-resistant bacteria. The pathogenic bacteria responsible for M. tuberculosis (Mtb) replicates within cells of the immune system called macrophages over a ~72h period, ultimately inducing cell death. There is broad evidence that vitamin D modulates macrophage responses to Mtb. Elevated levels of TB, particularly in vulnerable immigrant populations, have long been associated with vitamin D deficiency, suggesting that vitamin D supplementation may be of therapeutic benefit.<\/p>\n
The goal of this project is to fully understand the host macrophage response to Mtb infection through the use of cutting-edge genomics techniques and the role of vitamin D in boosting the host response against infection using similar techniques. The results of this project will allow the discovery of new immunization approaches and therapies to fight tuberculosis.<\/p>\n
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Co-applicants:<\/strong><\/p>\n \u00a0<\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-25760","financed-project","type-financed-project","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/genomequebec.com\/en\/wp-json\/wp\/v2\/financed-project\/25760","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/genomequebec.com\/en\/wp-json\/wp\/v2\/financed-project"}],"about":[{"href":"https:\/\/genomequebec.com\/en\/wp-json\/wp\/v2\/types\/financed-project"}],"wp:attachment":[{"href":"https:\/\/genomequebec.com\/en\/wp-json\/wp\/v2\/media?parent=25760"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}\n
\n Marcel<\/td>\n Behr<\/td>\n McGill University<\/td>\n<\/tr>\n \n Mathieu<\/td>\n Blanchette<\/td>\n McGill University<\/td>\n<\/tr>\n \n Maziar<\/td>\n Divangahi<\/td>\n McGill University<\/td>\n<\/tr>\n \n Suneil<\/td>\n Malik<\/td>\n Public Health Agency of Canada<\/td>\n<\/tr>\n \n Rob<\/td>\n Sladek<\/td>\n McGill University<\/td>\n<\/tr>\n \n Andrew F.<\/td>\n Smith<\/td>\n McGill University<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n